Map2k1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMap2k1 ELISA Kit for Rat(Rattus norvegicus)

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Map2k1 (Gene name),

Dual specificity mitogen-activated protein kinase kinase 1 (Protein name ), MP2K1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Map2k1(Mek1;Prkmk1);

Protein name:

Dual specificity mitogen-activated protein kinase kinase 1(MAP kinase kinase 1;MAPKK 1);

Alternative:

MAPK/ERK kinase 1(MEK 1);ERK activator kinase 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with MORG1 (By similarity). Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts with ARRB2. Interacts with VRK2.

Function:

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

393

Sequence:

50:

100:

150:

200:

250:

300:

350:

393:

DLKQLMVHAF | IKRSDAEEVD | FAGWLCSTIG | LNQPSTPTHA | ASI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q01986

SMR:

Q01986

UniGene:

Rn.5850

Pfam:

PF00069

KEGG:

rno:170851

STRING:

10116.ENSRNOP00000013933

Uniprot:

Q01986

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ELISA Kit for Rat MAP kinase kinase 1

Cat.:

E10995h

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96T

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ELISA Kit for Rat MAP kinase kinase 1

Cat.:

E10995m

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96T

ELISA Kit for Rat MAP kinase kinase 1

Cat.:

E10995r

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96T

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ELISA Kit for Rat MAP kinase kinase 1

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CLIA Kit for Rat MAP kinase kinase 1

Cat.:

U10995m

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Packing:

96T

CLIA Kit for Rat MAP kinase kinase 1

Cat.:

U10995h

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Manual:

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96T

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CLIA Kit for Rat MAP kinase kinase 1

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CLIA Kit for Rat MAP kinase kinase 1

Cat.:

U10995r

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96T

Polyclonal Antibody for Rat MAP kinase kinase 1

Cat.:

P10995Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAP kinase kinase 1

Monoclonal Antibody for Rat MAP kinase kinase 1

Protein for Rat MAP kinase kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase."
Wu J. , Harrison J.K. , Vincent L.A. , Haystead C. , Haystead T.A.J. , Michel H. , Hunt D.F. , Lynch K.R. , Sturgill T.W.
Proc. Natl. Acad. Sci. U.S.A.90:173-177(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Kidney.
2.

"Isolation of two members of the rat MAP kinase kinase gene family."
Otsu M. , Terada Y. , Okayama H.
FEBS Lett.320:246-250(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator."
Doering F. , Drewes G. , Berling B. , Mandelkow E.M.
Gene131:303-304(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
strain: Sprague-Dawley.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Thymus.
5.

Lubec G. , Chen W.-Q.
Submitted (2007-04) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 206-227; 270-291 AND 325-340;IDENTIFICATION BY MASS SPECTROMETRY
strain: Sprague-Dawley.
tissue: Hippocampus.
6.

"A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function."
Catling A.D. , Schaeffer H.J. , Reuter C.W. , Reddy G.R. , Weber M.J.
Mol. Cell. Biol.15:5214-5225(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;INTERACTION WITH RAF1;ENZYME REGULATION
7.

"MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade."
Schaeffer H.J. , Catling A.D. , Eblen S.T. , Collier L.S. , Krauss A. , Weber M.J.
Science281:1668-1671(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LAMTOR3;ENZYME REGULATION
8.

"A specific activation of the mitogen-activated protein kinase kinase 1 (MEK1) is required for Golgi fragmentation during mitosis."
Colanzi A. , Deerinck T.J. , Ellisman M.H. , Malhotra V.
J. Cell Biol.149:331-339(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;FUNCTION
9.

"Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds."
Luttrell L.M. , Roudabush F.L. , Choy E.W. , Miller W.E. , Field M.E. , Pierce K.L. , Lefkowitz R.J.
Proc. Natl. Acad. Sci. U.S.A.98:2449-2454(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
10.

"PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation."
Slack-Davis J.K. , Eblen S.T. , Zecevic M. , Boerner S.A. , Tarcsafalvi A. , Diaz H.B. , Marshall M.S. , Weber M.J. , Parsons J.T. , Catling A.D.
J. Cell Biol.162:281-291(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-298;ENZYME REGULATION
11.

"Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion."
Eblen S.T. , Slack-Davis J.K. , Tarcsafalvi A. , Parsons J.T. , Weber M.J. , Catling A.D.
Mol. Cell. Biol.24:2308-2317(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-292 AND SER-298;INTERACTION WITH MAPK1/ERK2;ENZYME REGULATION
12.

"The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes."
Nada S. , Hondo A. , Kasai A. , Koike M. , Saito K. , Uchiyama Y. , Okada M.
EMBO J.28:477-489(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE MAPK/ERK PATHWAY
13.

"Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector."
Willard F.S. , Willard M.D. , Kimple A.J. , Soundararajan M. , Oestreich E.A. , Li X. , Sowa N.A. , Kimple R.J. , Doyle D.A. , Der C.J. , Zylka M.J. , Snider W.D. , Siderovski D.P.
PLoS ONE4:E4884-E4884(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH BRAF; HRAS; MAPK3 AND RGS14
14.

"Signaling by dual specificity kinases."
Dhanasekaran N. , Premkumar Reddy E.
Oncogene17:1447-1455(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
15.

"The RAF proteins take centre stage."
Wellbrock C. , Karasarides M. , Marais R.
Nat. Rev. Mol. Cell Biol.5:875-885(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION
16.

"The ERK signaling cascade--views from different subcellular compartments."
Yao Z. , Seger R.
BioFactors35:407-416(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
17.

"The ERK cascade: distinct functions within various subcellular organelles."
Wortzel I. , Seger R.
Genes Cancer2:195-209(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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